Chlorine → HCID 19937923, 화합물

HRID 36801노트

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HRID 36801 반응식
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([F:18])=[C:10]([CH:17]=1)[NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])(=[O:4])=[O:3].[Cl:19]Cl>C(O)(=O)C.O>[Cl:19][C:7]1[C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:17][C:10]([NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])=[C:9]([F:18])[CH:8]=1

참가 물질

5

반응물 2

HCID 24526ChlorineHCID 19937925Ethyl 5-methylsulfonylamino-2-fluorocarbanilate

생성물 1

HCID 19937923HCID 19937923, 화합물수율 90%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

80.6 g (292 mmol) of ethyl 5-methylsulfonylamino-2-fluorocarbanilate was dissolved in a mixture of 1075 ml of acetic acid and 100 ml of water, and chlorine gas was added to the resultant solution at a temperature of not higher than 25° C. until the starting material disappeared. After the reaction was completed, the surplus chlorine gas was removed by blowing nitrogen gas thereinto, and hexane was added. The precipitates crystals were filtered out to obtain 81.4 g of the objective product (yield: 90%) in the form of yellow crystals.

후처리

  1. customthe surplus chlorine gas was removed
  2. additionhexane was added
  3. filtrationThe precipitates crystals were filtered out

출처 및 근거

ORD 기록
ord-37edf1745ff24e0d9bc9313ecf7b3020
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416236

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