Phenethylamine → 2-(Isoxazol-5-yl)-4-phenethylamino-6-ethyl-thieno-[2,3-d]-pyrimidine

반응식

[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:11]1[C:12]2[CH:24]=[C:23]([CH2:25][CH3:26])[S:22][C:13]=2[N:14]=[C:15]([C:17]2[O:21][N:20]=[CH:19][CH:18]=2)[N:16]=1>>[O:21]1[C:17]([C:15]2[N:16]=[C:11]([NH:9][CH2:1][CH2:2][C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)[C:12]3[CH:24]=[C:23]([CH2:25][CH3:26])[S:22][C:13]=3[N:14]=2)=[CH:18][CH:19]=[N:20]1

참가 물질

반응물 2

HCID 1001Phenethylamine

HCID 184600984-Chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

생성물 1

HCID 184603062-(Isoxazol-5-yl)-4-phenethylamino-6-ethyl-thieno-[2,3-d]-pyrimidine

실험 절차

With the procedure of Example 1, the reaction of phenethylamine with 4-chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-phenethylamino-6-ethyl-thieno-[2,3-d]-pyrimidine.

출처 및 근거

ORD 기록: ord-28fe549d4b1442f49e0b3f49c399ce84
출처 데이터셋: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06133271

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