5,6-dichloropyridine-3-carbonyl Chloride → 3-t-Butyl-5-(5,6-dichloro-3-pyridyl)-1,2,4-oxadiazole

HRID 368284노트

반응식

HRID 368284 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](Cl)=[O:10])[CH:5]=[N:6][C:7]=1[Cl:8].O[NH:13][C:14](=[NH:19])[C:15]([CH3:18])([CH3:17])[CH3:16]>C1(C)C=CC=CC=1>[C:15]([C:14]1[N:19]=[C:9]([C:4]2[CH:5]=[N:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[O:10][N:13]=1)([CH3:18])([CH3:17])[CH3:16]

참가 물질

4

반응물 2

HCID 27821565,6-dichloropyridine-3-carbonyl ChlorideHCID 178446865HCID 178446865, 화합물

생성물 1

HCID 232882723-t-Butyl-5-(5,6-dichloro-3-pyridyl)-1,2,4-oxadiazole수율 56%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 5,6-dichloro-pyridine-3-carbonyl chloride (1.8 g, 8.6 mmol) and N-hydroxy-2,2-dimethylpropanimidamide (1.0 g, 8.6 mmol) in toluene (40 mL) was stirred at room temperature for two hours and then heated under reflux for four hours. The mixture was cooled to room temperature and filtered through celite, the solids being washed with toluene (20 mL). Evaporation of the combined filtrates under reduced pressure gave the desired product (1.3 g, 56%) as a clear oil which crystallised on standing to a white solid, MP 98-101° C.

후처리

  1. temperatureheated
  2. temperatureunder reflux for four hours
  3. temperatureThe mixture was cooled to room temperature
  4. filtrationfiltered through celite
  5. washthe solids being washed with toluene (20 mL)
  6. customEvaporation of the combined filtrates under reduced pressure

출처 및 근거

ORD 기록
ord-a91589b60f7c45e6ae0ca46b4c1d3979
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133294

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