1,1-Dimethoxyethyl(dimethyl)amine → N-[1-(Dimethylamino)ethylidene]-5,6-dichloro-3-pyridinecarboxamide
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([NH2:11])=[O:10])[CH:5]=[N:6][C:7]=1[Cl:8].CO[C:14](OC)([N:16]([CH3:18])[CH3:17])[CH3:15]>>[CH3:17][N:16]([CH3:18])[C:14](=[N:11][C:9]([C:4]1[CH:5]=[N:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)=[O:10])[CH3:15]참가 물질
3
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 5,6-dichloro-3-pyridinecarboxamide (4.0 g, 0.02 mol), dimethylacetamide dimethyl acetal (8 mL) was heated in an oil bath at 120° C. for three hours. The reaction mixture was cooled to room temperature and the solid recrystallised from ethyl acetate:hexane in the presence of activated carbon to give the desired product (2.3 g, 42%) as an orange solid.
후처리
- temperatureThe reaction mixture was cooled to room temperature
- customthe solid recrystallised from ethyl acetate
출처 및 근거
- ORD 기록
- ord-8eaf96d195464ac18051453d2c2d61f1
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06133294
반응 노트
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