참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | 2-(Benzyloxy)propan-1-amine | HCID 296015 | — |
| 반응물 | 2-[(Tert-butyldimethylsilyl)oxy]-4-nitroaniline | HCID 15485710 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(2-Hydroxy-4-nitrophenyl)-N'-(2-benzyloxypropyl)urea | HCID 15485714 | 103% |
반응 단계
To a solution of 2-tert-butyldimethylsilyloxy-4-nitroaniline (300 mg, 1.125 mmol) in toluene (10 mL), triphosgene (126 mg, 0.45 mmol) and triethylamine (0.195 mL, 1.35 mmol) were added. The reaction mixture was stirred at 80° C. for 3 hours. Then it was cooled to room temperature and all solvent was evaporated. The residue was dissolved in DMF (1 mL) and 2-benzyloxypropylamine (185.6 mg, 1.125 mmol) was added. The reaction mixture was stirred at 80° C. for 16 hours. Chromatography of the resulting liquid on silica gel (50% Ethyl acetate/Hexane) gave desired product (160 mg, 41%). EI-MS m/z 346.4 (M+). mp: 64.6-65.2° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06133319 |
|---|
| 출처 데이터셋 | uspto-grants-2000_10 |
|---|
| ORD ID | ord-07e213e56cea42cebb574def8e748fdd |
|---|
| 출처 메모 | uspto-grants-2000_10 |
|---|
