N-Benzoyl-L-aspartic acid → N-benzoyl-L-aspartyl-L-phenylalanine methyl ester

HRID 36839

반응식

HRID 36839 반응식
[C:1]([NH:9][C@H:10]([C:15]([OH:17])=O)[CH2:11][C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][O:19][C:20](=[O:30])[C@H:21]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:22]>>[CH3:18][O:19][C:20](=[O:30])[C@H:21]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH:22][C:15](=[O:17])[C@H:10]([CH2:11][C:12](=[O:13])[OH:14])[NH:9][C:1](=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 205448N-Benzoyl-L-aspartic acidHCID 736234L-Phenylalanine, methyl ester

생성물 1

HCID 22853567N-benzoyl-L-aspartyl-L-phenylalanine methyl ester수율 64.2%

실험 절차

The procedure of Example 9 was followed excepting that: the quantity of N-benzoyl-L-aspartic acid was 2.85 g (10 mmol) and of the L-phenylalanine methyl ester was 2.69 g (15 mmol), in place of polyethylene glycol 600, polyethylene glycol 200 was used, the reaction time was 7 hours. N-benzoyl-L-aspartyl-L-phenylalanine methyl ester was obtained in the yield of 64.2%.

출처 및 근거

ORD 기록
ord-8af7348eff6e439ca9acd651f7754427
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05418146

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