Methanol → 3,5,6-Trifluoropyridin-2-amine
반응식
CO.C([NH:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1참가 물질
5
실험 절차
To 40 ml of methanol were added 7.60 g of the crude 2-benzylamino-3,5,6-trifluoropyridine as described above together with 0.55 g of 10% palladium on carbon and 2 ml acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure. The precipitate was dispersed in n-hexane, and collected by filtration to obtain 3.85 g of the title compound as a colorless solid.
후처리
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
- additionThe precipitate was dispersed in n-hexane
- filtrationcollected by filtration
출처 및 근거
- ORD 기록
- ord-a71a07fba67a43aca1637d0690172013
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06133284
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