Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylmorpholine → HCID 178511789, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylmorpholine | HCID 7525 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | L-Prolinamide | HCID 111306 | — |
| 반응물 | HCID 178418300 | HCID 178418300 | — |
| 반응물 | HCID 178523877 | HCID 178523877 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178511789 | HCID 178511789 | — |
반응 단계
Synthetic L-histidyl-L-proline diketopiperazine was prepared by coupling benzyloxycarbonyl-L-histidine (about 20 mmol, ICN) with L-prolineamide (about 20 mmol, Vega-Fox) in the presence of hydroxybenzotriazole (about 40 mmol, Aldrich), N-ethylmorpholine (about 20 mmol, Aldrich) and dicyclohexylcarbodiimide (about 20 mmol, Pierce). The solution in about 175 ml of dimethylformamide was stirred in an ice-bath for about 3 hours and then overnight at room temperature.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05418218 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-d44bc0d5c7ec48bea947f870e3b66ef2 |
| 출처 메모 | uspto-grants-1995_05 |