N,N-diethyl-m-toluamide → N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide

반응식

[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)[CH3:2].[CH3:15][Si:16](Cl)([CH3:18])[CH3:17]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[CH:6]=[C:7]([CH3:11])[CH:8]=[CH:9][C:10]=1[Si:16]([CH3:18])([CH3:17])[CH3:15])[CH3:14]

참가 물질

반응물 2

HCID 4284N,N-diethyl-m-toluamide

HCID 6397Chlorotrimethylsilane

생성물 1

HCID 18630275N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide수율 46%

실험 절차

These compounds were prepared from N,N-diethyl-3-methylbenzamide and 2.0 eq TMSCl according to General Method A. Purification by HPLC using 1:9 ethyl acetate/hexanes gave two products. Compound 63 was isolated as 6.0 g of a clear oil, a 46% yield. Compound 64 was isolated as 2.3 g of a clear oil, a 17% yield.

후처리

customPurification by HPLC
customgave two products

출처 및 근거

ORD 기록: ord-821f8b5598434dcaa2d02e9295f7a63a
출처 데이터셋: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06133252

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