Urea → 5-Chloro-1,3-dihydro-6-nitro-2H-benzimidazol-2-one

HRID 36867노트

반응식

HRID 36867 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:12])[C:5]([NH2:11])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].N[C:14](N)=[O:15]>>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]2[NH:11][C:14](=[O:15])[NH:12][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 1176UreaHCID 57026184-Chloro-5-nitro-o-phenylenediamine

생성물 1

HCID 145662265-Chloro-1,3-dihydro-6-nitro-2H-benzimidazol-2-one

실험 절차

A mixture of 14 g (0.074 mol) of 4-chloro-5-nitro-1,2-benzenediamine and of 13.44 g (0.226 mol) of urea is heated at 180° C. for 4 hours. The reaction mixture is cooled and evaporated to dryness. The residue is taken up in methanol and evaporated again. The residue is triturated in ether and a solid is obtained which is filtered. The product is used as is in the subsequent stages.

후처리

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness
  3. customevaporated again
  4. customThe residue is triturated in ether
  5. customa solid is obtained which
  6. filtrationis filtered

출처 및 근거

ORD 기록
ord-48938a94b76547d78882f6917891a754
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05418241

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