참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Carbon Dioxide | HCID 280 | — |
| 반응물 | 3,4-Dibromothiophene | HCID 18452 | — |
| 반응물 | HCID 178418306 | HCID 178418306 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Pentane | HCID 8003 | — |
| 생성물 | 4-Bromo-3-thenoic acid | HCID 85546 | 70.3% |
반응 단계
To a solution of 3,4-dibromothiophene (15 g, 62 mmol) in 80 mL ether under a positive nitrogen atmosphere was added dropwise 75 mL 1.7M t-BuLi in pentane at below -73° C. and the resulting reaction solution was stirred at -78° C. for 0.5 h. After that, the ether solution was poured into dry ice and extracted with water. The aq solution was washed with ether and then acidified with concentrated HCl. The solid was filtered and air-dried to give 9 g of 4-bromo-3-thiophenecarboxylic acid, yield 70.3%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06133252 |
|---|
| 출처 데이터셋 | uspto-grants-2000_10 |
|---|
| ORD ID | ord-6212e6e68c5b487ea0df8610456e50d7 |
|---|
| 출처 메모 | uspto-grants-2000_10 |
|---|
