Methyl methylthiosulphonate → 5-Chloro-n-(methylthio)-n-2-propenyl-3-(trimethylsilyl)-2-thiophenecarboxamide

HRID 368676노트

반응식

HRID 368676 반응식
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][CH:11]=[CH2:12])=[O:8])=[C:4]([Si:13]([CH3:16])([CH3:15])[CH3:14])[CH:3]=1.[CH3:17][S:18](=S)(OC)=O.C(N(SC)C(C1SC=CC=1[Si](C)(C)C)=O)C>>[Cl:1][C:2]1[S:6][C:5]([C:7]([N:9]([S:18][CH3:17])[CH2:10][CH:11]=[CH2:12])=[O:8])=[C:4]([Si:13]([CH3:14])([CH3:16])[CH3:15])[CH:3]=1

참가 물질

4

반응물 3

HCID 14573333Methyl methylthiosulphonateHCID 186301525-Chloro-N-(2-propenyl)-3-(trimethylsilyl)-2-thiophenecarboxamideHCID 18630304N-Ethyl-N-(methylthio)-3-(trimethylsilyl)-2-thiophene-carboxamide

생성물 1

HCID 186300365-Chloro-n-(methylthio)-n-2-propenyl-3-(trimethylsilyl)-2-thiophenecarboxamide

실험 절차

The compound of Example 262 (1.1 g) was reacted with 0.52 g of methyl methanethiosulfonate using procedure described for the preparation of the compound of Example 272. The title compound (0.6 g) was purified by flash chromatography with 2% ethyl acetate-hexane and recovered as a colorless oil. nD25 1.5698.

후처리

  1. customThe title compound (0.6 g) was purified by flash chromatography with 2% ethyl acetate-hexane
  2. customrecovered as a colorless oil

출처 및 근거

ORD 기록
ord-89f24271ce544872a970ffc105fdaa8f
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133252

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