Potassium Hydroxide → 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran

HRID 36874노트

반응식

HRID 36874 반응식
Br[CH:2]1[CH:7]([OH:8])[C:6]2[CH:9]=[C:10]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][C:5]=2[O:4][C:3]1([CH3:21])[CH3:20].[OH-].[K+]>C(OCC)C>[CH3:20][C:3]1([CH3:21])[CH:2]2[O:8][CH:7]2[C:6]2[CH:9]=[C:10]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][C:5]=2[O:4]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 193706513-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol

생성물 1

HCID 199363903,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran수율 96.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

후처리

  1. customsynthesized
  2. additionwas added
  3. customThe insoluble material was removed by filtration
  4. customthe solvent was removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-fe95702c48d94bb29eb304e32c6b377b
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05418232

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