Methanol → HCID 18421413, 화합물

반응식

C([O:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([C:9]([CH3:19])=[C:10]([CH2:17]Br)[C:11](=[O:16])[O:12]2)=[CH:7][CH:6]=1)(=O)C.[CH3:20][OH:21]>>[CH3:19][C:9]1[C:8]2[C:13](=[C:14]([CH3:15])[C:5]([OH:4])=[CH:6][CH:7]=2)[O:12][C:11](=[O:16])[C:10]=1[CH2:17][O:21][CH3:20]

참가 물질

반응물 2

HCID 887Methanol

HCID 18421399HCID 18421399, 화합물

생성물 1

HCID 18421413HCID 18421413, 화합물

실험 절차

7-acetoxy-3-bromomethyl-4,8-dimethylcoumarin (2.50 g, 8.90 mmol) was refluxed in methanol (300 mL) overnight, cooled to room temperature and concentrated under vacuum to give crude 4,8-dimethyl-7-hydroxy-3-methoxymethylcoumarin. 1H NMR (CD3OD): δ 7.52 (d, J=8.8 Hz, 1H), 6.83 (d, J=8.8 Hz, 1H), 4.50 (s, 2H), 3.41 (s, 3H), 2.49 (s, 3H), 2.25 (s, 3H).

후처리

concentrationconcentrated under vacuum

출처 및 근거

ORD 기록: ord-473c7233a392481781583aae14048843
출처 데이터셋: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06133460

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