Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2,5-Dimethyl-3-[[1-(phenylmethyl)piperidin-4-yl]thio]-1H-indole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| 반응물 | 4-[(2-Oxopropyl)thio]-1-(phenylmethyl)piperidine | HCID 15229280 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2,5-Dimethyl-3-[[1-(phenylmethyl)piperidin-4-yl]thio]-1H-indole hydrochloride | HCID 19936613 | — |
반응 단계
Paratolylhydrazine hydrochloride (20 g) is added to a solution of 4-[(2-oxopropyl)thio]-1-(phenylmethyl)piperidine (33.2 g, prepared in Example 9) in isopropanol (150 ml) under nitrogen. After 30 minutes, the solution is cooled to 0° C. and saturated with gaseous hydrogen chloride. After 4 hours at room temperature, the precipitate formed is filtered off, washed with water and then taken up in hot ethanol. After cooling, the white crystals of 2,5-dimethyl-3-[[1-(phenylmethyl)piperidin-4-yl]thio]-1H-indole hydrochloride (28.3 g) are filtered off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05418242 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-4f490eb7d2cd474bb50970b706eda0f4 |
| 출처 메모 | uspto-grants-1995_05 |