Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate → Methyl 2-(3-hydroxypropyl)benzoate
반응식
[OH:1][CH2:2][C:3]#[C:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[H][H]>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]참가 물질
5
실험 절차
Step 2--A mixture of methyl o-(1-hydroxy-2-propyn-3-yl)benzoate (CXIX, 5.91 g) in methanol (60 ml) is hydrogenated at 40 psi hydrogen for 9 hrs using a total of 900 mg. Palladium on carbon (10%) is added in equal portions three times during the course of the reaction. The reaction is filtered and concentrated to give the saturated ester, methyl o-(1-hydroxyprop-3-yl)benzoate (CXXI).
후처리
- filtrationThe reaction is filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e0de1580f71946f48cc1c4c8def22125
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06133446
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