Homoveratrylamine → N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

HRID 368998

반응식

HRID 368998 반응식
[C:1]([O:11]C)(=O)[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH2:25])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH:25][C:1](=[O:11])[CH:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[OH:3])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

참가 물질

3

반응물 2

HCID 8421HomoveratrylamineHCID 78066(+-)-Methyl mandelate

생성물 1

HCID 596397N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

실험 절차

33.2 g (0.2 Mol) of methyl mandelate and 72 g (0.4 Mol) of 2-(3,4-dimethoxyphenyl)-ethylamine are heated to 160-165° C. under an N2 atmosphere with stirring, for 5 hours using a descending condenser (to remove the methanol released). The cooled residue is dissolved in 300 ml of ethyl acetate, washed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution, dried over MgSO4 and distilled off from the solvent.

후처리

  1. customto remove the methanol
  2. dissolutionThe cooled residue is dissolved in 300 ml of ethyl acetate
  3. washwashed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution
  4. dry with materialdried over MgSO4
  5. distillationdistilled off from the solvent

출처 및 근거

ORD 기록
ord-dcac017363dc466e9fefe95c7fe9a456
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136819

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