Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → Isopropyl Hydrogen Phenylmalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Phenylmalonic acid | HCID 75791 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Isopropyl Hydrogen Phenylmalonate | HCID 19042994 | 60% |
반응 단계
Phenylmalonic acid (13.5 g, 0.07 mol ) in dry ether (40 mL) was treated with thionyl chloride (8.92 g, 5.4 mL, 0.07 mol) and one drop of N,N-dimethylformamide. The mixture was heated at 40°-50° C. for 3 hours. The clear solution was evaporated under reduced pressure to remove any residual thionyl chloride. The oily residue was redissolved in dry ether (40 mL), and the solution was treated with isopropyl alcohol (0.075 mol, 5.76 mL), refluxed for 2 hours and worked up as before to give the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05418244 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-af73ff0456864c18a081b75ef0069f5f |
| 출처 메모 | uspto-grants-1995_05 |