Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 8-Bromo-1,7-naphthyridin-6-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-(Cyanomethyl)pyridine-2-carbonitrile | HCID 4672598 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 8-Bromo-1,7-naphthyridin-6-amine | HCID 10704335 | — |
반응 단계
Through a stirred solution of 2-Cyano-3-pyridylacetonitrile (3.6 g, 0.025 mol) in toluene (80 ml) is bubbled HBr for 5 h. Then, 4N NaOH is carefully added and the suspension stirred vigorously. The mixture is filtered and the product washed with water and dried. Crystallisation from toluene affords the title compound. Mass M+H 225. Melting point 188° C., decomposition.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06136821 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-fa42714f177d4e05807418139671021e |
| 출처 메모 | uspto-grants-2000_10 |