Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 4-[N-(benzylidene)aminomethyl]-1-(2-pyridinesulphonyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Pyridine-2-sulfonyl Chloride | HCID 3787675 | — |
| 반응물 | N-Benzylidene(piperidin-4-yl)methanamine | HCID 11820173 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-[N-(benzylidene)aminomethyl]-1-(2-pyridinesulphonyl)piperidine | HCID 23284888 | 68.4% |
반응 단계
Triethylamine (6.3 ml) was added to a cloudy solution of N-benzylidene-4-piperidylmethylamine (4.05 g) and pyridine-2-sulphonyl chloride (4.0 g) in dichloromethane (100 ml) and the resulting clear yellow solution was stirred for 14 hours. Removal of the solvent under reduced pressure gave a yellow solid which on addition of diethyl ether (100 ml) partly dissolved. The insoluble white solid (triethylamine hydrochloride) was removed by filtration. Evaporation of the filtrate afforded a flocculent yellow solid which recrystallised from ethanol to give 4-[N-(benzylidene)aminomethyl]-1-(2-pyridinesulphonyl)piperidine as a white crystalline solid (4.7 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06136825 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-af024818ab744dabafd169752ca52401 |
| 출처 메모 | uspto-grants-2000_10 |