Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (S)N-(2-mercapto-1-oxo-3-phenylpropyl) D-Tryptophan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | L-Tryptophan | HCID 6305 | — |
| 반응물 | D-Tryptophan | HCID 9060 | — |
| 반응물 | (S)-2-(benzoylthio)-3-phenylpropanoic acid | HCID 9878985 | — |
| 반응물 | (R)-2-(benzoylthio)-3-phenylpropanoic acid | HCID 9943761 | — |
| 생성물 | (S)N-(2-mercapto-1-oxo-3-phenylpropyl) D-Tryptophan | HCID 57125133 | — |
반응 단계
The operation is carried out as in Stage 1 of Example 24 using, instead of the hydrochloride of the methyl ester of L-Tryptophan, the hydrochloride of the methyl ester of D-Tryptophan and, instead of (R)-2-(benzoylthio)-3-phenylpropanoic acid, (S)-2-(benzoylthio)-3-phenylpropanoic acid (prepared according the same reference). After purification by chromatography on silica with a methylene chloride-ethyl acetate: 95-5 mixture as eluant, 564 mg of expected product (SR isomer) (colourless foam) is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06136842 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-0fa0366102284a0d975afc5404871b5f |
| 출처 메모 | uspto-grants-2000_10 |