Methylamine → HCID 23284793, 화합물

HRID 369216노트

반응식

HRID 369216 반응식
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17](F)[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([NH:2][CH3:1])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 108619991-(3-Amino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

생성물 1

HCID 23284793HCID 23284793, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A 40% aqueous solution (100 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, ethanol was added to the residue, and the mixture was left to stand overnight. Solids deposited were collected by filtration to obtain the title compound (40 mg) as a colorless powder.

후처리

  1. distillationAfter the solvent was distilled off under reduced pressure, ethanol
  2. additionwas added to the residue
  3. waitthe mixture was left
  4. waitto stand overnight
  5. filtrationSolids deposited were collected by filtration

출처 및 근거

ORD 기록
ord-4ccf6755664042708f7d529fb37989c9
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

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