Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 1-(5-amino-2,4-difluorophenyl)-6-fluoro-7-methylamino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 1-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid | HCID 11089970 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 1-(5-amino-2,4-difluorophenyl)-6-fluoro-7-methylamino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid | HCID 23284661 | — |
반응 단계
A 40% aqueous solution (150 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (150 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, ethanol was added to the residue, and solids deposited were collected by filtration to obtain the title compound (40 mg) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06136823 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-e99a34072b8e41049ffc0f8de8b8b5aa |
| 출처 메모 | uspto-grants-2000_10 |