Methylamine → 1-(5-amino-2,4-difluorophenyl)-6-fluoro-7-methylamino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

HRID 369229

반응식

HRID 369229 반응식
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:27])=[CH:6][C:7]([F:26])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:21])=[C:17](Cl)[N:18]=3)[C:13](=[O:22])[C:12]([C:23]([OH:25])=[O:24])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:27])=[CH:6][C:7]([F:26])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:21])=[C:17]([NH:2][CH3:1])[N:18]=3)[C:13](=[O:22])[C:12]([C:23]([OH:25])=[O:24])=[CH:11]2)[CH:9]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 110899701-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

생성물 1

HCID 232846611-(5-amino-2,4-difluorophenyl)-6-fluoro-7-methylamino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A 40% aqueous solution (150 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (150 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, ethanol was added to the residue, and solids deposited were collected by filtration to obtain the title compound (40 mg) as colorless crystals.

후처리

  1. distillationAfter the solvent was distilled off under reduced pressure, ethanol
  2. additionwas added to the residue, and solids
  3. filtrationdeposited were collected by filtration

출처 및 근거

ORD 기록
ord-e99a34072b8e41049ffc0f8de8b8b5aa
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

연결된 노트

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