Potassium Nitrate → 1-Bromo-4-fluoro-5-methyl-2-nitrobenzene

HRID 369238

반응식

HRID 369238 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1.[N+:10]([O-])([O-:12])=[O:11].[K+]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 1235275-Bromo-2-fluorotoluene

생성물 1

HCID 232846641-Bromo-4-fluoro-5-methyl-2-nitrobenzene수율 104.5%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

5-Bromo-2-fluorotoluene (7.65 g) was added to concentrated sulfuric acid (40 ml), and potassium nitrate (4.2 g) was added portionwise to the mixture at -20° C. The temperature of the reaction mixture was given back to room temperature to conduct stirring for 3 days, and then poured into ice water to conduct extraction with ethyl acetate. After an organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off to obtain the title compound (9.9 g) as a pale yellow oil.

후처리

  1. additionwas added portionwise to the mixture at -20° C
  2. customwas given back to room temperature
  3. extractionextraction with ethyl acetate
  4. dry with materialAfter an organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-6f2bc81ea0144785a0dd9ea6908bf2aa
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

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