1-Bromo-4-fluoro-5-methyl-2-nitrobenzene → 2-Bromo-5-fluoro-4-methylaniline

HRID 369239노트

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HRID 369239 반응식
[Br:1][C:2]1[C:3]([N+:10]([O-])=O)=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10]

참가 물질

4

반응물 1

HCID 232846641-Bromo-4-fluoro-5-methyl-2-nitrobenzene

생성물 1

HCID 27733792-Bromo-5-fluoro-4-methylaniline수율 93.4%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

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온도
70 °C

실험 절차

Iron powder (18.5 g) was added to a solution of 5-bromo-2-fluoro-4-nitrotoluene (9.7 g) in acetic acid (30 ml), and the mixture was stirred at 70° C. for 3 hours. The catalyst was removed by filtration through Celite, and the filtrate was washed with chloroform. The solvent and the like in the filtrate were distilled off under reduced pressure. The residue was subjected to column chromatography on silica gel to conduct elution with chloroform, thereby obtaining the title compound (7.9 g) as a red oil.

후처리

  1. customThe catalyst was removed by filtration through Celite
  2. washthe filtrate was washed with chloroform
  3. distillationThe solvent and the like in the filtrate were distilled off under reduced pressure
  4. washelution with chloroform

출처 및 근거

ORD 기록
ord-b35a5741b64740b282bda99be200b36e
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

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