Potassium Nitrate → 2-Chloro-4-fluoro-5-methyl-3-nitrobenzoic acid

HRID 369243노트

반응식

HRID 369243 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:10]([N+:13]([O-:15])=[O:14])=[C:9]([F:11])[C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 23284674Benzoic acid, 2-chloro-4-fluoro-5-methyl-

생성물 1

HCID 232847252-Chloro-4-fluoro-5-methyl-3-nitrobenzoic acid수율 91%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

2-Chloro-4-fluoro-5-methylbenzoic acid (2.0 g) was added to concentrated sulfuric acid (20 ml) to dissolve it, and potassium nitrate (1.07 g) was added portionwise to the solution under ice cooling. After the addition, the temperature of the reaction mixture was given back to room temperature to conduct stirring overnight. The reaction mixture was poured into ice water and extracted with diethyl ether. After an organic layer was collected and dried over anhydrous magnesium sulfate, the solvent was distilled off to obtain the title compound (2.25 g) as a reddish brown oil.

후처리

  1. additionwas added portionwise to the solution under ice cooling
  2. additionAfter the addition
  3. customwas given back to room temperature
  4. extractionextracted with diethyl ether
  5. customAfter an organic layer was collected
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-7734ae73e96846fc8d9d7bda4d119a84
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

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