Ethyl Acetate → Indane

HRID 36926

반응식

HRID 36926 반응식
ClC1C=CC=CC=1C(Cl)=O.N[C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][CH2:16][CH2:15]2.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>O>[CH2:17]1[C:18]2[C:14](=[CH:13][CH:12]=[CH:20][CH:19]=2)[CH2:15][CH2:16]1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 691102-Chlorobenzoyl chlorideHCID 90496Indan-5-amine

생성물 1

HCID 10326Indane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Chlorobenzoyl chloride (11.8 g) was added dropwise to a stirred mixture of 5-aminoindan (9.0 g), potassium carbonate (9.3 g), ethyl acetate (90 ml) and water (90 ml) under ice-cooling. The mixture was further stirred under ice-cooling for one hour, at the end of which time the organic layer was separated, washed with water, dried (MgSO4) and distilled to remove the solvent. The procedure gave crystals of 5-2-chlorobenzoylamino)indan. The crystals were collected by filtration and recrystallized from isopropyl ether to give colorless needles, m.p. 144°-145° C.

후처리

  1. temperaturecooling
  2. temperaturecooling for one hour, at the end of which time the organic layer
  3. customwas separated
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. distillationdistilled
  7. customto remove the solvent

출처 및 근거

ORD 기록
ord-88d69e93a5f6475badf02e8876958cbe
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05418239

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