Potassium Nitrate → HCID 23284719, 화합물

HRID 369325노트

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HRID 369325 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1.[N+:30]([O-])([O-:32])=[O:31].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:7]([N+:30]([O-:32])=[O:31])=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 23284684HCID 23284684, 화합물

생성물 1

HCID 23284719HCID 23284719, 화합물수율 89.9%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Ethyl 1-(4-fluoro-2-methylphenyl)-6-fluoro-8-methyl-7-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1.1 g) was added to concentrated sulfuric acid (10 ml), and potassium nitrate (330 mg) was added to the mixture under ice cooling. The resultant mixture was stirred at room temperature for 4 days. The reaction mixture was poured into ice water and extracted with chloroform. A chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off to obtain the title compound (1.1 g) as a pale yellow amorphous substance.

후처리

  1. additionwas added to the mixture under ice cooling
  2. extractionextracted with chloroform
  3. dry with materialA chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-530f1049adc94f5e894da2bf7485d109
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06136823

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