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Sodium Methoxide → HCID 23284768, 화합물

HRID 369329
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인쇄 미리보기

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HRID 369329 반응식
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[C:6]([F:29])=[CH:7][C:8]([F:28])=[C:9]([N:11]2[C:20]3[C:15](=[CH:16][C:17]([F:23])=[C:18](F)[C:19]=3[CH3:21])[C:14](=[O:24])[C:13]([C:25]([OH:27])=[O:26])=[CH:12]2)[CH:10]=1>C(O)(=O)C.CO>[NH2:4][C:5]1[C:6]([F:29])=[CH:7][C:8]([F:28])=[C:9]([N:11]2[C:20]3[C:15](=[CH:16][C:17]([F:23])=[C:18]([O:2][CH3:1])[C:19]=3[CH3:21])[C:14](=[O:24])[C:13]([C:25]([OH:27])=[O:26])=[CH:12]2)[CH:10]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 11132289HCID 11132289, 화합물

생성물 1

HCID 23284768HCID 23284768, 화합물수율 80.2%

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

Methanol (500 mg) and sodium methoxide (28% methanol solution; 200 mg) were added to 1-(5-amino-2,4-difluorophenyl)-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (350 mg), and the mixture was heated and stirred at 40° C. for 2 days. Acetic acid (2 drops) was added to the reaction mixture to collect solids by filtration. The solids were washed with ethanol and dried to obtain the title compound (290 mg) as a pale yellow powder.

후처리

  1. temperaturethe mixture was heated
  2. customto collect solids
  3. filtrationby filtration
  4. washThe solids were washed with ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-6fb135c7383b43d49875bf49532921cc
출처 데이터셋
uspto-grants-2000_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06136823

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