HCID 18462171, 화합물 → HCID 15434652, 화합물

HRID 369485노트

반응식

HRID 369485 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([O-])=O>CO>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

참가 물질

3

반응물 1

HCID 18462171HCID 18462171, 화합물

생성물 1

HCID 15434652HCID 15434652, 화합물수율 97.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 4-nitro-3-octoxybenzoate (8.7 g, 0.028 mol) was dissolved in 150 mL methanol to form a solution. It was stirred at room temperature in the presence of 10% Pd--C under H2 atmosphere for 29 hours. The reaction mixture was filtered through celite, concentrated to give the product methyl 4-amino-3-octoxybenzoate as an off-white solid (7.6 g, 96%). 1H NMR (300 MHz, CDCl3): 7.25 (d, J=2.1 Hz, 1H), MS calcd (C16H25NO3): 279.2; found: 279.0.

후처리

  1. customto form a solution
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8ffda926189c4560beb6156b0188ecfc
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06137003

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