Benzamide → 4'-Nitrobenzanilide

HRID 369491노트

반응식

HRID 369491 반응식
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O-:12])=[O:11]>>[N+:10]([C:13]1[CH:18]=[CH:17][C:16]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:15][CH:14]=1)([O-:12])=[O:11]

참가 물질

3

반응물 2

HCID 2331BenzamideHCID 7416Nitrobenzene

생성물 1

HCID 769304'-Nitrobenzanilide

실험 절차

According to the recently released paper in line with the direct manufacture of amide compound formed by the NASH reaction, it is reported that benzamide is reacted with nitrobenzene in the presence of TMA(OH) to isolate N-(4-nitrophenyl)benzamide, a relatively stable intermediate, and then methanol and ammonia are added to the mixture and reacted under a pressure reactor to prepare 4-nitroaniline as a final product, while regenerating benzamide (J. Org. Chem., 1993, 58(24), 6883-8; WO No. 93/24447).

후처리

  1. customformed by the NASH reaction, it

출처 및 근거

ORD 기록
ord-c2591c8af2394bc5a21b9b9ce58b6387
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06137010

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