참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Methyl 4'-hydroxy(1,1'-biphenyl)-4-carboxylate | HCID 1490289 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 생성물 | Methyl-4'-(cis-9-octadecenyloxy)-4-biphenylcarboxylate | HCID 70012153 | 41% |
반응 단계
DEAD (676 mg, 3.88 mmol) was added via syringe with stirring and under argon, to a solution of ester 27 (590 mg, 2.59 mmol), alcohol 26b (707 mg, 2.64 mmol), and TPP (1.018 g, 3.88 mmol) in 8 ml dry THF. The reaction mixture was stirred overnight under argon at 25° C. and then treated with 30% hydrogen peroxide. Ether was added (approximately 20 ml) and the organic layer was separated, washed with brine, and dried over MgSO4. The crude product was adsorbed onto silica gel and purified via flash chromatography with elutions of 95/5 and 90/10 (v/v) (Hex/EtOAc), respectively. Evaporation of solvent yielded 505 mg (41%) of a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06139771 |
|---|
| 출처 데이터셋 | uspto-grants-2000_10 |
|---|
| ORD ID | ord-c1454863aaa84ffca2f2ba3859a215ce |
|---|
| 출처 메모 | uspto-grants-2000_10 |
|---|
