Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfadiazine → N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-2-[[2-[[4-(pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]phenyl]disulfanyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfadiazine | HCID 5215 | — |
| 반응물 | 2,2'-Dithiodibenzoyl chloride | HCID 88164 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-2-[[2-[[4-(pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]phenyl]disulfanyl]benzamide | HCID 465350 | 58.2% |
반응 단계
This compound was prepared according to the general methods described in Example 1 using 2,2'-dithiobisbenzoyl chloride (3.0 g, 8.7 mmol) in 30 mL dichloromethane and 4-amino-N-(2-pyrimidinyl) benzenesulfonamide (5.3 g, 21.7 mmol) in 100 mL pyridine. The crude product was recrystallized from a mixture of dimethylformamide, ethanol, and water to yield 3.9 g of the title compound, mp 280° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05734081 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-7d4b3e2d8b104f55b15cbffa0a456209 |
| 출처 메모 | uspto-grants-1998_03 |