2-(Chloromethyl)thiophene → (E)-4-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-3-(2-thienyl)methyl-3-butenoic Acid

HRID 36982

반응식

HRID 36982 반응식
[CH2:1]([C:5]1[N:6]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[C:7](/[CH:10]=[C:11](\[CH2:17][C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)/[CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].ClC[C:33]1[S:34][CH:35]=[CH:36][CH:37]=1>>[CH2:1]([C:5]1[N:6]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[C:7](/[CH:10]=[C:11](\[CH2:17][C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)/[CH:12]([CH2:16][C:33]2[S:34][CH:35]=[CH:36][CH:37]=2)[C:13]([OH:15])=[O:14])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 2

HCID 698302-(Chloromethyl)thiopheneHCID 70043244(E)-4-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-methyl-3-(2-thienyl)methyl-3-butenoic acid

생성물 1

HCID 70044041(E)-4-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-3-(2-thienyl)methyl-3-butenoic Acid

실험 절차

This compound is prepared according to the procedure of Example 14(i, ii) using less than one equivalent of 2-chloromethylthiophene in place of methyl iodide.

후처리

  1. customThis compound is prepared

출처 및 근거

ORD 기록
ord-07ee8a774b9b4c79a8437c6eba64e690
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05418250

연결된 노트

불러오는 중…