Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromomethyl 2-methoxyphenyl ketone → 2-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromomethyl 2-methoxyphenyl ketone | HCID 123440 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Ethyl 2-carbamimidoylacetate hydrochloride | HCID 15555354 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole | HCID 23282699 | — |
반응 단계
Analogously to Step 8.1, 14.5 g (87 mmol) of 2-amidino-acetic acid ethyl ester hydrochloride in 150 ml of abs. ethanol are reacted with 5.9 g (87 mmol) of sodium ethanolate and 10.3 g (44 mmol) of 2-bromo-1-(2-methoxy-phenyl)-ethan-1-one (2-bromo-2'-methoxy-acetophenone; Aldrich; Milwaukee/USA) to form the title compound; m.p.: 128° C.; TLC-Rf =0.25 (hexane/ethyl acetate [2:1]).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06140332 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-2a49f028cf6f4743b9ad849985078b6a |
| 출처 메모 | uspto-grants-2000_10 |