2-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine → Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone

HRID 369883노트

반응식

HRID 369883 반응식
[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2CC2C=CC=CC=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

4

반응물 1

HCID 232826462-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine

생성물 1

HCID 550904Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone수율 92.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

In ethanol (300 ml) is suspended 5% palladium-carbon (3 g), and thereto is added 2-(1-pyrrolidinyl)carbonyl-1-benzylpyrrolidine (30 g), and the mixture is subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The mixture is filtered, and the filtrate is concentrated under reduced pressure to remove the solvent to give 2-(1-pyrrolidinyl)carbonylpyrrolidine (about 18 g) as an oily product.

후처리

  1. customis subjected to catalytic hydrogenation at room temperature under atmospheric pressure
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customto remove the solvent

출처 및 근거

ORD 기록
ord-3fc5a98fccb24020a84daa4a512926d3
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140330

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