3-Methoxy-4-methoxycarbonylcinnamic acid → 3-(3-Methoxy-4-methoxycarbonylphenyl)propionic acid
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])[CH:6]=[CH:7][C:8]([OH:10])=[O:9]>C(O)(=O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15]참가 물질
4
실험 절차
To a suspension of 3-methoxy-4-methoxycarbonylcinnamic acid (8.35 g) in acetic acid (200 ml) is added 10% palladium-carbon (1.0 g), and the mixture is subjected to hydrogenation at room temperature. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is crystallized from diethyl ether-n-hexane to give 3-(3-methoxy-4-methoxycarbonylphenyl)propionic acid (7.5 g).
후처리
- customis subjected to hydrogenation at room temperature
- customThe catalyst is removed by filtration
- concentrationthe filtrate is concentrated under reduced pressure
- customThe residue is crystallized from diethyl ether-n-hexane
출처 및 근거
- ORD 기록
- ord-c7f664acf0934378873049caccf90656
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06140330
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