Trifluoroacetic acid → 4-[(3,4-Dichlorophenyl)carbonyl]piperidine

HRID 369926노트

반응식

HRID 369926 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[Cl:21])[C:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:23]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 53945757Tert-butyl 4-(3,4-dichlorobenzoyl)piperidine-1-carboxylate

생성물 1

HCID 124044204-[(3,4-Dichlorophenyl)carbonyl]piperidine수율 99.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a room temperature solution of 4-(3,4-dichlorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester (3.8 g, 10.6 mmol) in methylene chloride (100 mL) was added trifluoroacetic acid (25 mL) and the solution was stirred for 1 h. After removing the organics, ethyl acetate (200 mL) was added and the resulting solution was basified with 1N aqueous sodium hydroxide solution. The ethyl acetate layer was separated, dried with magnesium sulfate and concentrated to give 4-(3,4-dichlorobenzoyl)piperidine (2.73 g) as a white solid.

후처리

  1. customAfter removing the organics, ethyl acetate (200 mL)
  2. additionwas added
  3. customThe ethyl acetate layer was separated
  4. dry with materialdried with magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2b92475429204c4cb48cf7e4bd5d6dee
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140344

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