Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Chloro-2-nitrobenzoic acid | HCID 17286 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Chloro-2-nitrobenzoyl chloride | HCID 2723685 | 104.5% |
반응 단계
To a suspension of 5-chloro-2-nitrobenzoic acid (21 g, 100 mmol) in dry methylene chloride (200 mL) at 0° C. were added several drops of DMF, followed by oxalyl chloride (13 mL, 150 mmol). The reaction was warmed to ambient temperature. After 16 hours the solvents were removed and the viscous oil dried in vacuo to afford 23 g (quantitative yield) of 5-chloro-2-nitrobenzoyl chloride; NMR (CDCl3) 8.1 (d, 1), 7.7 (m, 2) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06140351 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-334ab236062a4121888a04ebcb61115d |
| 출처 메모 | uspto-grants-2000_10 |