Iodine → 2-Iodo-4-methylaniline

HRID 370357

반응식

HRID 370357 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[I:14]I>C(Cl)Cl.O>[I:14][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[NH2:1]

참가 물질

6

반응물 3

HCID 807IodineHCID 7813p-ToluidineHCID 516892Sodium Bicarbonate

생성물 1

HCID 27640002-Iodo-4-methylaniline

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of p-toluidine (5 g, 46.7 mmol) in methylene chloride (25 mL) was added a solution of sodium bicarbonate (4.7 g, 56 mmol) in water (75 mL). Then was added iodine (11.26 g, 44.33 mmol) in small portions and the mixture was stirred for 16 hours at room temperature. The reaction was quenched with saturated NaHSO3 and the product was extracted with methylene chloride. The methylene chloride layer was washed with brine, dried over Na2SO4, and evaporated in vacuo to give a crude 2-iodo-4-methylaniline.

후처리

  1. customThe reaction was quenched with saturated NaHSO3
  2. extractionthe product was extracted with methylene chloride
  3. washThe methylene chloride layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-03feabe7ed0f49ca985286056400081a
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140499

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