Tetrahydrofuran → N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

HRID 370375노트

반응식

CN(O)[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22].C([N:27]([CH2:30]C)CC)C.Cl[CH2:33][O:34][C:35](=[O:37])[CH3:36].C1C[O:41]CC1>>[CH3:30][NH:27][O:41][CH2:33][O:34][C:35](=[O:37])[CH2:36][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22]

참가 물질

반응물 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 69366Chloromethyl acetate

HCID 20275650HCID 20275650, 화합물

생성물 1

HCID 86740180N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

실험 절차

To a solution of N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]hydroxyamine (700 mg, 1.93 mmol) in THF (10 ml) containing triethylamine (1.2 eq.) is added chloromethylacetate (2 eq.). The mixture is stirred at RT overnight. Excess THF is removed and the product is evaporated to dryness and purified to give N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine.

후처리

customExcess THF is removed
customthe product is evaporated to dryness
custompurified

출처 및 근거

ORD 기록: ord-06264be53c1c4997ae34a1e86f5bd9a6
출처 데이터셋: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04526608

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