Formic Acid → 6-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazine

반응식

[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:9][NH2:10])=[CH:6][C:7]=1[CH3:8].[CH:11](O)=O>>[CH3:8][C:7]1[C:2]([Cl:1])=[N:3][N:4]2[CH:11]=[N:10][N:9]=[C:5]2[CH:6]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 123768133-Chloro-6-hydrazinyl-4-methylpyridazine

생성물 1

HCID 8197966-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazine

실험 절차

13.4 Grams (0.0845 mole) of 3-chloro-4-methyl-6-hydrazinopyridazine are dissolved in 100 milliliters of aqueous 88 percent formic acid. The mixture is heated at the boiling temperature under reflux for 2 hours. The mixture is evaporated under reduced pressure and the 7-methyl-6-chloro-s-triazolo[4,3-b]pyridazine intermediate product is obtained as a residue. The residue is triturated with diethyl ether, and found to melt at a temperature of 157.5°-158° C.

후처리

temperatureThe mixture is heated at the boiling temperature
temperatureunder reflux for 2 hours
customThe mixture is evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-2e044734cf3b4fb2b40bb6374d07745a
출처 데이터셋: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04526890

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