참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 3-Aminobenzoic Acid | HCID 7419 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-(Dimethylamino)benzoic acid | HCID 66837 | — |
| 반응물 | Crystal Violet lactone | HCID 73773 | — |
| 반응물 | 4,4'-Bis(dimethylamino)benzhydrol | HCID 92742 | — |
| 생성물 | 2-(Bis(4-(dimethylamino)phenyl)methyl)-5-(dimethylamino)benzoic acid | HCID 102063 | — |
반응 단계
U.S. Pat. No. 2,417,897 and its corresponding U.S. Pat. No. Re. 23,024, which issued Mar. 25, 1947 and Aug. 17, 1948, respectively, disclose a three-step process for the preparation of 3,3-bis(4-dimethylaminophenyl)-6-dimethylaminophthalide, Crystal Violet Lactone (CVL). In the first step, 3-dimethylaminobenzoic acid is prepared from 3-aminobenzoic acid by alkylating the free amine using methyl iodide in the presence of potassium hydroxide. In the second step, the 3-dimethylaminobenzoic acid is condensed with 4,4'-bis(dimethylamino)benzhydrol in the presence of sulfuric acid to obtain 2-[bis(4-dimethylaminophenyl)methyl]-5-dimethylaminobenzoic acid. In the third step, the 2-[bis(4-dimethylaminophenyl)methyl]-5-dimethylaminobenzoic acid is oxidized using lead dioxide in dilute hydrochloric acid to obtain the CVL.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04528136 |
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| 출처 데이터셋 | uspto-grants-1985_07 |
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| ORD ID | ord-511bc6b7428042eca90bc26db83c6f3c |
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| 출처 메모 | uspto-grants-1985_07 |
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