Formaldehyde → 7-(3,4-Dimethyl-1-piperazinyl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxlic acid

HRID 370715노트

반응식

HRID 370715 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:21])=[C:10]([N:14]3[CH2:19][CH2:18][NH:17][CH:16]([CH3:20])[CH2:15]3)[C:11]=2[F:13])[C:6](=[O:22])[C:5]([C:23]([OH:25])=[O:24])=[CH:4]1)[CH3:2].[CH2:26]=O>C(O)=O>[CH3:20][CH:16]1[N:17]([CH3:26])[CH2:18][CH2:19][N:14]([C:10]2[C:11]([F:13])=[C:12]3[C:7]([C:6](=[O:22])[C:5]([C:23]([OH:25])=[O:24])=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[F:21])[CH2:15]1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 3948Lomefloxacin

생성물 1

HCID 134776637-(3,4-Dimethyl-1-piperazinyl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxlic acid

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A mixture of 1.40 g of 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, 2.8 ml of 90% formic acid and 2.2 ml of 37% formalin was heated for 4 hours under reflux. The reaction mixture was evaporated and the residue was dissolved in water. The solution was neutralized with aqueous sodium bicarbonate. The precipitate was filtered and recrystallized from ethanol to give 0.32 g of the title compound as colorless needles, M.p. 211.5°-212° C.

후처리

  1. temperaturewas heated for 4 hours
  2. temperatureunder reflux
  3. customThe reaction mixture was evaporated
  4. dissolutionthe residue was dissolved in water
  5. filtrationThe precipitate was filtered
  6. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-841b7245c77b43c88fd1851b8beb19af
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528287

반응 노트

불러오는 중…