Acetic Acid → 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone

HRID 370752노트

반응식

HRID 370752 반응식
O[CH:2]([CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[C:3](O)=[O:4].[NH3:16].[NH2:17]N.C(O)(=O)C>O>[OH:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:7]1[CH:6]=[CH:2][C:3](=[O:4])[NH:16][N:17]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 222Ammonia2회HCID 9321HydrazineHCID 13778436HCID 13778436, 화합물

생성물 1

HCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinone수율 85%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred suspension of 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid in water was added ammonia until pH 7.0 was attained. Hydrazine was added slowly with the concurrent addition of sufficient glacial acetic acid to maintain a pH of 7.0. Steam heating was applied for 2 hours and during this time the pH of 7.0 was maintained by the addition of ammonia as necessary. The reaction mixture was allowed to cool to room temperature. The solid was filtered off, washed with water, 2-propanol and dried (MgSO4) to afford 6-(2-hydroxyphenyl)-3(2H)-pyridazinone (85%).

후처리

  1. temperatureto maintain a pH of 7.0
  2. temperatureSteam heating
  3. filtrationThe solid was filtered off
  4. washwashed with water, 2-propanol
  5. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-caf4335781aa4d75bb4cdf7359c0a5b8
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528371

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