Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (2-{2-[(Carboxy-phenyl-methyl)-carbamoyl]phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | (2-{2-[(tert-Butoxycarbonyl-phenyl-methyl)carbamoyl]-phenyldisulfanyl}-benzoylamino)phenyl-acetic acid tert-butyl ester | HCID 76120819 | — |
| 용매 | Diethylether hexane | HCID 21584099 | — |
| 생성물 | (2-{2-[(Carboxy-phenyl-methyl)-carbamoyl]phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid | HCID 465365 | 42.5% |
반응 단계
This compound was prepared according to the procedure described in Example 50 using [R-(R*,R*)] (2-{2-[(tert-butoxycarbonyl-phenyl-methyl)-carbamoyl]-phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid tert-butyl ester (0.2 g, 0.3 mmol) from Example 38, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The crude product was stirred with ether/hexane and filtered to afford 73.0 mg of the title compound, mp 231°-232° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05734081 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-90c1ac43b2814299a03384dc402e2956 |
| 출처 메모 | uspto-grants-1998_03 |