Thionyl Chloride → N-Methyl 4-Methylbenzimidoyl Chloride

HRID 370910노트

반응식

HRID 370910 반응식
[CH3:1][NH:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][CH:5]=1.S(Cl)([Cl:14])=O>>[CH3:1][N:2]=[C:3]([Cl:14])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 140377N-Methyl-p-toluamide

생성물 1

HCID 12410496N-Methyl 4-Methylbenzimidoyl Chloride수율 80%

실험 절차

N-Methyl 4-methylbenzamide (10.02 g, 67.2 mmole) was treated with thionyl chloride (31.7 g, 267 mmole) as in Example I. Gas evolution ceased after the reaction had been heated for 45 minutes. The product was isolated as in Example I to yield 9.0 g (80%) of the title compound as a clear colorless liquid, b.p. 57° C. (~0.1 mm Hg).

후처리

  1. temperaturehad been heated for 45 minutes
  2. customThe product was isolated as in Example I

출처 및 근거

ORD 기록
ord-2c187e162997469ab1326661be35710b
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528382

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