Thionyl Chloride → N-Cyclohexyl 4-Chlorobenzimidoyl Chloride

반응식

[CH:1]1([NH:7][C:8](=O)[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:19])=O>>[CH:1]1([N:7]=[C:8]([Cl:19])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 2254614-Chloro-N-cyclohexylbenzamide

생성물 1

HCID 13477600N-Cyclohexyl 4-Chlorobenzimidoyl Chloride

실험 절차

N-Cyclohexyl 4-chlorobenzamide (12.8 g, 53.9 mmole) and thionyl chloride (43.14 g, 363 mmole) were heated at reflux with stirring for 1.75 hours. Excess thionyl chloride was removed by distillation. The title compound was isolated by distillation (b.p. 130° C. at ~15 mm Hg) to yield 7.4 g (54%) of a clear colorless liquid which crystallized upon cooling.

후처리

temperatureat reflux
customExcess thionyl chloride was removed by distillation

출처 및 근거

ORD 기록: ord-1a7be2027218483d9b1209200e215c66
출처 데이터셋: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04528382

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