Thionyl Chloride → N-Octyl 4-Chlorobenzimidoyl Chloride

HRID 370916노트

반응식

HRID 370916 반응식
[CH2:1]([NH:9][C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].S(Cl)([Cl:21])=O>>[CH2:1]([N:9]=[C:10]([Cl:21])[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 17219574-chloro-N-octylbenzamide

생성물 1

HCID 13477601N-Octyl 4-Chlorobenzimidoyl Chloride수율 77%

실험 절차

N-Octyl 4-chlorobenzamide (17.2 g, 64.2 mmole) and thionyl chloride (42.59 g, 358 mmole) were stirred and heated at reflux for one hour. The product was isolated by fractional distillation at reduced pressure (b.p. 70°-90° C. at 15 mm Hg) to yield 14.0 g (77%) of impure title compound.

후처리

  1. temperatureheated
  2. temperatureat reflux for one hour
  3. customThe product was isolated by fractional distillation at reduced pressure (b.p. 70°-90° C. at 15 mm Hg)

출처 및 근거

ORD 기록
ord-d8717f55b0014481a130076770b05e2f
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528382

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